Itomi Seiko, Okumura Akihisa, Ikuta Taketo, Negoro Tamiko, Watanabe Kazuyoshi
Department of Pediatrics, Nagoya First Red Cross Hospital, Nagoya, Aichi, Japan.
Brain Dev. 2007 Mar;29(2):121-3. doi: 10.1016/j.braindev.2006.07.001. Epub 2006 Aug 28.
We reported a child with refractory partial seizures successfully managed by clinical desensitization to phenytoin. The patient had ischemic brain lesions due to cardiopulmonary arrest at 39 weeks of corrected age. He had complex partial seizures refractory to several antiepileptic drugs since 4 years of age. At 8 years 1 month of age, phenytoin was first administered. Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued. At 8 years 8 months of age, desensitization was attempted because of refractoriness of seizures to drugs other than phenytoin. Desensitization was started at 1mg daily, and then the dose was doubled every week. His seizures were controlled by 150mg/day of phenytoin in combination with primidone. No problems have been observed during desensitization.
我们报告了一名难治性部分性癫痫患儿，通过对苯妥英进行临床脱敏成功得到治疗。该患者在矫正年龄39周时因心肺骤停出现缺血性脑损伤。自4岁起，他患有复杂部分性癫痫，对多种抗癫痫药物均难治。在8岁1个月时首次服用苯妥英。服用苯妥英10天后出现发热和斑丘疹，随后停用该药。在8岁8个月时，由于癫痫对苯妥英以外的药物难治，尝试进行脱敏治疗。脱敏治疗从每日1毫克开始，然后每周剂量加倍。他的癫痫通过每天150毫克苯妥英联合扑米酮得到控制。脱敏过程中未观察到问题。
