Maldonado-Báez Lymarie, Wendland Beverly
The Johns Hopkins University, Department of Biology, 3400 N. Charles St, Baltimore, MD 21218, USA.
Trends Cell Biol. 2006 Oct;16(10):505-13. doi: 10.1016/j.tcb.2006.08.001. Epub 2006 Aug 28.
Clathrin-dependent endocytosis allows cells to bring plasma membrane and extracellular molecules into the cell. Forming a clathrin-coated vesicle requires the sequential action of numerous factors, beginning with endocytic adaptors. Adaptors are thought to initiate the process in two ways: by selecting cargo for packaging into the vesicle and assembling the clathrin coat and other components necessary to shape the vesicle. Here, we review recent work focusing on the sequential and cooperative interactions of adaptors with their binding partners, and how adaptors contribute to initial stages of endocytic internalization. The regulation of adaptors might be a key step for controlling endocytosis, and thus aid in homeostasis and cell physiology.
网格蛋白介导的内吞作用使细胞能够将质膜和细胞外分子摄入细胞内。形成网格蛋白包被囊泡需要众多因子的顺序作用，起始于内吞衔接蛋白。衔接蛋白被认为通过两种方式启动这一过程：选择货物分子包装进囊泡以及组装网格蛋白衣被和塑造囊泡所需的其他成分。在此，我们综述了近期的研究工作，这些工作聚焦于衔接蛋白与其结合伴侣的顺序和协同相互作用，以及衔接蛋白如何促进内吞内化的初始阶段。衔接蛋白的调控可能是控制内吞作用的关键步骤，从而有助于体内平衡和细胞生理功能。
