使用西门子/CTI化学过程控制单元（CPCU）全自动制备无载体4-[18F]氟苯甲酸和N-琥珀酰亚胺基4-[18F]氟苯甲酸酯。
Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU).
作者信息
Marik Jan, Sutcliffe Julie L
机构信息
Department of Biomedical Engineering, University of California Davis, 451 East Health Sciences Drive, CA 95616-5294, USA.
出版信息
Appl Radiat Isot. 2007 Feb;65(2):199-203. doi: 10.1016/j.apradiso.2006.06.007. Epub 2006 Aug 28.
The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77+/-5% (n=4) for [18F]FBA and 46+/-5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.
使用改良的西门子/CTI化学过程控制单元（CPCU）双容器[18F]FDG模块制备了广泛使用的双功能标记试剂4-[18F]氟苯甲酸（[18F]FBA）及其活化形式N-琥珀酰亚胺基4-[18F]氟苯甲酸酯（[18F]SFB）。得到的产物放射化学产率大于99%，[18F]FBA的衰变校正产率为77±5%（n = 4），[18F]SFB的衰变校正产率为46±5%（n = 4）。所展示的合成程序具有高度可重复性且完全自动化。
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