结合甲基睾酮的酯化雌激素会使绝经后女性的眼压升高。

Esterified estrogens combined with methyltestosterone raise intraocular pressure in postmenopausal women.

作者信息

Khurana Rahul N, LaBree Laurie D, Scott Garrett, Smith Ronald E, Yiu Samuel C

机构信息

Ocular Surface Center, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.

出版信息

Am J Ophthalmol. 2006 Sep;142(3):494-5. doi: 10.1016/j.ajo.2006.04.018.

DOI:10.1016/j.ajo.2006.04.018

PMID:16935599

Abstract

PURPOSE

To investigate the effect of esterified estrogens combined with methyltestosterone (EECM) (Estratest, Solvay, Pharmaceuticals, Inc, Baudette, Minnesota, USA) on intraocular pressure (IOP) in postmenopausal women.

DESIGN

Observational case series.

METHODS

The IOP of 13 consecutive postmenopausal women with dry eye syndrome were recorded before and during EECM therapy (1.25 mg of esterified estrogens and 2.5 mg of methyltestosterone for several months).

RESULTS

The mean IOP increased from a baseline of 15.0 mm Hg before treatment to 18.2 mm Hg on EECM therapy (P < .0001) after a median duration of 11.3 months (range, 0.9 to 24 months). The increase in IOP was statistically significant at the 0.05 level of significance within three months and continued over 12 months. Two patients whose pressures increased (>4 mm Hg) returned to baseline levels after EECM was discontinued.

CONCLUSIONS

Esterified estrogens combined with methyltestosterone produce a clinically significant increase in IOP in postmenopausal women with dry eye syndrome.

摘要

目的

探讨结合雌激素与甲基睾酮（EECM）（商品名Estratest，美国苏威制药公司，明尼苏达州鲍德特）对绝经后女性眼压（IOP）的影响。

设计

观察性病例系列。

方法

记录13例患有干眼综合征的绝经后女性在接受EECM治疗前及治疗期间（服用1.25mg结合雌激素和2.5mg甲基睾酮数月）的眼压。

结果

在中位治疗时长11.3个月（范围0.9至24个月）后，眼压均值从治疗前的基线值15.0mmHg升高至接受EECM治疗时的18.2mmHg（P <.0001）。眼压升高在3个月内具有统计学显著意义（显著性水平为0.05），并持续超过12个月。2例眼压升高（>4mmHg）的患者在停用EECM后眼压恢复至基线水平。