Seckin Hakan, Yigitkanli Kazim, Ilhan Ozgur, Han Unsal, Bavbek Murad
Neurosurgery Department, Ministry of Health, Diskapi Educational and Research Hospital, Ankara, Turkey.
Surg Neurol. 2006 Sep;66(3):324-7; discussion 327. doi: 10.1016/j.surneu.2005.11.056.
The simultaneous occurrence of meningioma and breast cancer with or without brain metastasis is an unusual but well-known event. However, contiguous occurrence of meningioma and brain cancer metastasis is a less rare evidence and we are aware of only one previously published case in the literature.
A 72-year-old woman presented with headache, nausea and vomiting, and diminished mentation and memory. Seven years ago, she had had simple mastectomy at another hospital. Histopathologic examination had been reported as breast carcinoma. The patient had not gone to the controls and was unaware of the diagnosis. Cranial MRI examination of the patient showed two extraaxial masses. Histopathologic examination of the lesion at the frontal convexity, which was reported as en plaque meningioma radiologically, revealed meningioma but the other tumor at the sylvian fossa resembling the other meningioma was reported as breast carcinoma metastasis at histopathologic examination.
Although meningiomas have well-known radiological features, the other pathologies like breast metastasis may simulate them. A possible hormonal relationship between breast cancer and meningioma has not been clarified. We are not sure that this has played a role in dissociation of both tumor cells in our case.
同时出现脑膜瘤和乳腺癌伴或不伴脑转移是一种不常见但已为人知的情况。然而，脑膜瘤与脑癌转移灶相邻出现的情况并非罕见，而我们所知文献中此前仅报道过一例。
一名72岁女性出现头痛、恶心、呕吐，以及精神状态和记忆力减退。七年前，她在另一家医院接受了单纯乳房切除术。组织病理学检查报告为乳腺癌。患者未进行后续复查，也不知道诊断结果。该患者的头颅磁共振成像（MRI）检查显示有两个脑外肿块。组织病理学检查显示，额部凸面的病变在影像学上报告为扁平状脑膜瘤，病理结果为脑膜瘤；而在外侧裂池类似脑膜瘤的另一个肿瘤在组织病理学检查中报告为乳腺癌转移灶。
尽管脑膜瘤有众所周知的影像学特征，但其他病变如乳腺转移瘤可能与之相似。乳腺癌与脑膜瘤之间可能存在的激素关系尚未明确。我们不确定这在我们病例中两种肿瘤细胞的分离过程中是否起了作用。
