Giraud A S, Jackson C, Menheniott T R, Judd L M
Department of Medicine, University of Melbourne at Western Hospital, Footscray, Australia.
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G1-5. doi: 10.1152/ajpgi.00382.2006. Epub 2006 Aug 24.
Gastric trefoil peptides mediate mucosal repair by stimulating cell migration, inhibiting apoptosis and inflammation, and likely augmenting the barrier function of mucus. One of these, tff1, is a gastric-specific tumor suppressor gene, which when repressed is associated with gastric cancer progression. IL-6 family cytokines play an important role in maintaining gastric homeostasis by regulating tff1 and other mediators of mucosal proliferation, inflammation, angiogenesis, and apoptosis. In this review the signaling cascades downstream of the common IL-6 cytokine family coreceptor gp130 that contribute to control of this homeostasis are described, as are the pathological outcomes of imbalancing these pathways.
胃三叶因子肽通过刺激细胞迁移、抑制细胞凋亡和炎症反应以及可能增强黏液的屏障功能来介导黏膜修复。其中之一，tff1，是一种胃特异性肿瘤抑制基因，当其受到抑制时与胃癌进展相关。IL-6家族细胞因子通过调节tff1以及黏膜增殖、炎症、血管生成和细胞凋亡的其他介质，在维持胃内环境稳定中发挥重要作用。在本综述中，描述了共同的IL-6细胞因子家族共受体gp130下游有助于控制这种内环境稳定的信号级联反应，以及这些途径失衡的病理结果。
