Singer K H, Le P T, Denning S M, Whichard L P, Haynes B F
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
J Invest Dermatol. 1990 Jun;94(6 Suppl):85S-90S. doi: 10.1111/1523-1747.ep12876038.
Interaction of T lymphocytes with other cell types is important for normal T-cell development and function. Recently, a number of adhesion molecules important in T-cell interactions with other cell types have been defined. In this paper we review the role of two adhesion pathways, CD2/LFA-3 and LFA-1/ICAM-1, in T-cell interactions with epithelial cells of the thymus and skin. While thymic epithelium-T-cell interactions were mediated by both the LFA-1/ICAM-1 pathway and the CD2/LFA-3 pathway, epidermal-T-cell interactions were mediated primarily by the LFA-1/ICAM-1 pathway. Although ICAM-1 was not expressed in vivo on epidermal keratinocytes in normal skin, ICAM-1 was expressed by epidermal keratinocytes at the site of T-cell infiltration in inflammatory dermatitis. ICAM-1 was expressed in vivo on thymic epithelium. Both LFA-3 and ICAM-1 were expressed on epithelial cells of thymus and skin early on in fetal ontogeny. These antigen-independent adhesion molecules play an important role in the cell-cell interactions associated with T-cell differentiation and function.
T淋巴细胞与其他细胞类型的相互作用对于正常T细胞的发育和功能至关重要。最近，已经确定了许多在T细胞与其他细胞类型相互作用中起重要作用的黏附分子。在本文中，我们综述了两条黏附途径，即CD2/LFA-3和LFA-1/ICAM-1，在T细胞与胸腺和皮肤上皮细胞相互作用中的作用。胸腺上皮细胞与T细胞的相互作用由LFA-1/ICAM-1途径和CD2/LFA-3途径介导，而表皮与T细胞的相互作用主要由LFA-1/ICAM-1途径介导。虽然在正常皮肤中，ICAM-1在体内未在表皮角质形成细胞上表达，但在炎症性皮炎中T细胞浸润部位的表皮角质形成细胞表达ICAM-1。ICAM-1在体内表达于胸腺上皮。LFA-3和ICAM-1在胎儿发育早期就表达于胸腺和皮肤的上皮细胞。这些不依赖抗原的黏附分子在与T细胞分化和功能相关的细胞间相互作用中起重要作用。
