血小板活化因子对大鼠腹膜肥大细胞组胺释放的影响。

The effect of platelet-activating factor on histamine release from rat peritoneal mast cells.

作者信息

Misawa M, Huang S C

机构信息

Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

出版信息

Jpn J Pharmacol. 1990 May;53(1):75-80. doi: 10.1254/jjp.53.75.

DOI:10.1254/jjp.53.75

PMID:1693706

Abstract

The effect of platelet-activating factor (PAF) on histamine release from peritoneal mast cells of adult and young male rats was investigated. PAF alone tended to release histamine from the mast cells of adult and young rats, although very slightly. On the other hand, PAF significantly inhibited the histamine release induced by the Ca2+ ionophore A23187 in mast cells obtained from rats of either age group, but not that by compound 48/80. Such inhibition was not seen with lyso-PAF. CV-3988, a PAF antagonist, antagonized the inhibitory effect of PAF on the A23187-induced histamine release in mast cells from adult and young rats. These results suggest that PAF does not have a strong histamine-liberating action on mast cells, and that PAF inhibits the calcium influx into mast cells through the activation of PAF receptors.

摘要

研究了血小板活化因子（PAF）对成年和幼年雄性大鼠腹膜肥大细胞组胺释放的影响。单独的PAF虽非常轻微，但倾向于使成年和幼年大鼠肥大细胞释放组胺。另一方面，PAF显著抑制从任一年龄组大鼠获取的肥大细胞中由Ca2+离子载体A23187诱导的组胺释放，但不抑制由化合物48/80诱导的组胺释放。溶血PAF未见此类抑制作用。PAF拮抗剂CV-3988拮抗PAF对成年和幼年大鼠肥大细胞中A23187诱导的组胺释放的抑制作用。这些结果表明，PAF对肥大细胞没有强烈的组胺释放作用，且PAF通过激活PAF受体抑制钙流入肥大细胞。