核转运中的原子分辨率结构。
Atomic resolution structures in nuclear transport.
作者信息
Süel Katherine E, Cansizoglu Ahmet E, Chook Yuh Min
机构信息
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390-9041, USA.
出版信息
Methods. 2006 Aug;39(4):342-55. doi: 10.1016/j.ymeth.2006.06.015.
Abstract
There are currently at least 53 structures of components of nuclear transport in the Protein Databank. In addition to providing critical insights into molecular mechanisms of nuclear transport, these atomic resolution structures provide a large body of information that could guide biochemical and cell biological analyses involving nuclear transport proteins. This paper catalogs 53 crystal and NMR structures of nuclear transport proteins, with the emphasis on providing information useful for mutagenesis and overexpression of recombinant proteins.
摘要
目前，蛋白质数据库中至少有53种核转运组件的结构。这些原子分辨率的结构不仅为核转运的分子机制提供了关键见解，还提供了大量信息，可指导涉及核转运蛋白的生化和细胞生物学分析。本文编录了53种核转运蛋白的晶体结构和核磁共振结构，重点是提供对重组蛋白诱变和过表达有用的信息。
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