Wagner G
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Struct Biol. 1997 Oct;4 Suppl:841-4.
With the ability to determine atomic resolution structures of biological macromolecules in semi-physiological conditions, nuclear magnetic resonance spectroscopy (NMR) has become an eminent tool in structural biology. NMR provides a means for studying critical biological phenomena including protein structure, dynamics and folding as well as a practical approach to drug design.
凭借在半生理条件下确定生物大分子原子分辨率结构的能力,核磁共振光谱法(NMR)已成为结构生物学中的一项杰出工具。NMR为研究包括蛋白质结构、动力学和折叠在内的关键生物学现象提供了一种手段,也是药物设计的一种实用方法。