Weingard Kerri K
Urocare Associates, Garden City, NY, USA.
Urol Nurs. 2006 Aug;26(4):261-9; quiz 270.
Men with locally advanced and nonmetastatic prostate cancer are generally treated with androgen deprivation therapy (ADT) to suppress tumor growth. This treatment, however, is associated with decreased bone density and increased fracture risk, which can lead to increased morbidity and mortality. Nurses play a key role in patient education by promoting lifestyle changes such as diet and exercise that can improve bone strength and decrease risk of ADT-associated bone loss. Pharmacologic interventions using bisphosphonates can significantly reduce bone loss and fracture risk in patients with prostate cancer receiving ADT.
患有局部晚期和非转移性前列腺癌的男性通常接受雄激素剥夺疗法（ADT）以抑制肿瘤生长。然而，这种治疗与骨密度降低和骨折风险增加有关，这可能导致发病率和死亡率上升。护士在患者教育中发挥关键作用，通过促进饮食和运动等生活方式的改变，这些改变可以增强骨骼强度并降低ADT相关骨质流失的风险。使用双膦酸盐的药物干预可以显著降低接受ADT的前列腺癌患者的骨质流失和骨折风险。
