短暂暴露于吗啡后，豚鼠离体回肠可重复性的戒断收缩：可乐定和硝苯地平的作用

Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine.

作者信息

Valeri P, Martinelli B, Morrone L A, Severini C

机构信息

Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.

出版信息

J Pharm Pharmacol. 1990 Feb;42(2):115-20. doi: 10.1111/j.2042-7158.1990.tb05364.x.

DOI:10.1111/j.2042-7158.1990.tb05364.x

PMID:1693956

Abstract

Guinea-pig ileum stored for 30 min in Krebs solution and then mounted in Tyrode solution gave reproducible contracture responses to naloxone after brief exposure to morphine. The preparation lasted for several hours and a variety of pharmacological tests could be made. Clonidine, an alpha 2-adrenoceptor agonist, and nifedipine, a calcium channel antagonist, both known to interfere with tolerance and physical dependence, inhibited naloxone withdrawal contractures in a dose related way. Their action seemed to be receptor-mediated since yohimbine and Bay k 8644, respectively, reversed their inhibitory effect.

摘要

豚鼠回肠在克雷布斯溶液中储存30分钟，然后置于台氏液中，短暂接触吗啡后对纳洛酮产生可重复的挛缩反应。该标本可持续数小时，可进行多种药理学测试。可乐定（一种α2肾上腺素能受体激动剂）和硝苯地平（一种钙通道拮抗剂），二者均已知会干扰耐受性和身体依赖性，以剂量相关的方式抑制纳洛酮戒断挛缩。它们的作用似乎是受体介导的，因为育亨宾和Bay k 8644分别逆转了它们的抑制作用。