Bay K 8644对激动剂诱导的回肠收缩的增强作用。
Potentiating effect of Bay K 8644 on agonist-induced ileal contractions.
作者信息
Gacar N M, Kalyoncu N I, Aksoy Z, Sivrikaya N, Ugurbas O, Mollaoglu A H, Caglar M
机构信息
Department of Pharmacology and Toxicology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Pol J Pharmacol. 1993 Jul-Aug;45(4):413-9.
The effects of Bay K 8644 on agonist-induced ileal contractions were investigated. Histamine, serotonin and a acetylcholine (10(-8)-10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 1076 mg. Bay K 8644 (10(-6) M) increased the potency of histamine and serotonin-induced ileal contractions, but acetylcholine induced responses were not increased. All responses of agonists were inhibited by nifedipine (10(-6) M). This inhibition was decreased with increasing acetylcholine concentrations. These results suggest that histamine and serotonin induced/mediated contractions in guinea-pig ileum are independent of calcium influx through voltage operated channels.
研究了Bay K 8644对激动剂诱导的回肠收缩的影响。组胺、5-羟色胺和乙酰胆碱（10⁻⁸ - 10⁻⁴M）产生剂量依赖性收缩。10⁻⁵M 5-羟色胺可产生最大收缩。其值为1076毫克。Bay K 8644（10⁻⁶M）增加了组胺和5-羟色胺诱导的回肠收缩的效力，但乙酰胆碱诱导的反应未增加。激动剂的所有反应均被硝苯地平（10⁻⁶M）抑制。随着乙酰胆碱浓度增加，这种抑制作用减弱。这些结果表明，组胺和5-羟色胺在豚鼠回肠中诱导/介导的收缩与通过电压门控通道的钙内流无关。
Zotero 插件