Singh Mahender
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Virol J. 2006 Aug 29;3:60. doi: 10.1186/1743-422X-3-60.
Enormous effort has been devoted to the development of a vaccine against human immunodeficiency virus (HIV). But it is proving to be an unprecedented challenge to create an effective vaccine mainly due to the high genetic variability of the virus and the necessity of cytotoxic T lymphocytes (CTL) for containing the infection. Currently pursued vaccine strategies appear to induce CTL in nonhuman primate models but in the early clinical trials, these strategies fail to fully control the viral infection. New strategies that can cover the vast genetic diversity of HIV are needed for the development of a potent vaccine.
人们为开发一种抗人类免疫缺陷病毒（HIV）的疫苗付出了巨大努力。但事实证明，研发一种有效的疫苗是一项前所未有的挑战，主要原因是该病毒的高基因变异性以及细胞毒性T淋巴细胞（CTL）在控制感染方面的必要性。目前所采用的疫苗策略似乎能在非人灵长类动物模型中诱导CTL产生，但在早期临床试验中，这些策略未能完全控制病毒感染。开发一种有效的疫苗需要新的策略来涵盖HIV的巨大基因多样性。
