Forman R, Robinson J, Egan D, Ross C, Gosden B, Barlow D
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Fertil Steril. 1990 Jul;54(1):169-70. doi: 10.1016/s0015-0282(16)53657-7.
Three patients had an undetected pregnancy when they commenced a GnRH-a on the 21st day of their cycle before ovulation stimulation for IVF. Two of the three pregnancies were later diagnosed as ectopic gestations. Based on this and previous case reports in the literature, it is suggested that luteal phase administration of GnRH-a may predispose to EPs, particularly in patients with damaged tubes, by reducing tubal motility secondary to a transient increase in circulating P concentrations.
三名患者在进行体外受精排卵刺激前的月经周期第21天开始使用促性腺激素释放激素激动剂（GnRH-a）时，已怀有未被检测出的身孕。这三例妊娠中有两例后来被诊断为异位妊娠。基于此以及文献中先前的病例报告，有人提出，黄体期给予GnRH-a可能会因循环中孕酮（P）浓度短暂升高导致输卵管蠕动减弱，从而使患者（尤其是输卵管受损的患者）易发生异位妊娠（EPs）。
