韩国一家三级护理医院葡萄球菌分离株中诱导型克林霉素耐药性的患病率。
Prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital.
作者信息
Lim Hwan Sub, Lee Hyukmin, Roh Kyoung Ho, Yum Jong Hwa, Yong Dongeun, Lee Kyungwon, Chong Yunsop
机构信息
Department of Laboratory Medicine, Kwandong University College of Medicine, Kyunggi, Korea.
出版信息
Yonsei Med J. 2006 Aug 31;47(4):480-4. doi: 10.3349/ymj.2006.47.4.480.
Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus aureus and 1,043 isolates of coagulase-negative staphylococci (CNS) were tested for inducible resistance by the D-zone test. Overall, 17% of MRSA, 84% of MSSA, 37% of MRCNS, and 70% of MSCNS were susceptible to clindamycin. Of the erythromycin non-susceptible, clindamycin-susceptible isolates, 32% of MRSA, 35% of MSSA, 90% of MRCNS, and 94% of MSCNS had inducible clindamycin resistance. Inducible clindamycin resistance in staphylococci was highly prevalent in Korea. This study indicates importance of the D-zone test in detecting inducible clindamycin resistance in staphylococci to aid in the optimal treatment of patients.
葡萄球菌属对克林霉素的耐药性可以是组成型的，也可以是诱导型的。诱导型耐药不能通过传统的抗菌药物敏感性试验检测出来。在本研究中，我们确定了韩国一家三级医疗中心葡萄球菌分离株中诱导型克林霉素耐药性的流行情况。在2004年2月至9月期间，采用D试验对1519株金黄色葡萄球菌分离株和1043株凝固酶阴性葡萄球菌（CNS）分离株进行诱导型耐药性检测。总体而言，17%的耐甲氧西林金黄色葡萄球菌（MRSA）、84%的甲氧西林敏感金黄色葡萄球菌（MSSA）、37%的耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）和70%的甲氧西林敏感凝固酶阴性葡萄球菌（MSCNS）对克林霉素敏感。在对红霉素不敏感但对克林霉素敏感的分离株中，32%的MRSA、35%的MSSA、90%的MRCNS和94%的MSCNS具有诱导型克林霉素耐药性。葡萄球菌中诱导型克林霉素耐药性在韩国非常普遍。本研究表明D试验在检测葡萄球菌诱导型克林霉素耐药性以帮助患者进行最佳治疗方面具有重要意义。
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