Tanaka Hirohiko, Kihira Tomohisa, Nomura Yoshiyuki, Ishihara Akinori
Department of Obstetrics and Gynecology, Mie Prefectural Shima Hospital, 1257 Ugata, Ago, Shima, Mie 517-0595, Japan.
J Infect Chemother. 2006 Aug;12(4):220-3. doi: 10.1007/s10156-006-0450-2.
The efficacy and toxicity of salvage chemotherapy with a combination of irinotecan hydrochloride (CPT-11) and mitomycin C (MMC) in elderly Japanese patients with gynecological malignancies are reported. Six patients, aged 75 years or older, two with stage IV uterine cervical cancer and four with platinum- and taxane-resistant ovarian cancer, were treated. CPT-11 (120 mg/m(2)) was administered intravenously for 4 h with 500 ml of normal saline solution, followed by 3.5 mg/m(2) of MMC with 100 ml of normal saline, administered for 60 min, on days 1 and 15 and every 5 weeks thereafter. Six patients received a total of 24 courses of treatment, which provided an opportunity to explore, in a preliminary manner, the efficacy and toxicity of this approach. All patients demonstrated reasonable tolerance to this management strategy. There were no deaths attributable to toxicity. In a carefully selected patient population, CPT-11 and MMC chemotherapy could be administered to elderly Japanese patients with gynecological malignancies. Phase I and II studies are needed to confirm the feasibility of this treatment.
报告了盐酸伊立替康（CPT-11）与丝裂霉素C（MMC）联合挽救性化疗在老年日本妇科恶性肿瘤患者中的疗效和毒性。治疗了6例年龄在75岁及以上的患者，其中2例为IV期子宫颈癌，4例为铂类和紫杉烷耐药的卵巢癌。CPT-11（120mg/m²）与500ml生理盐水静脉滴注4小时，随后在第1天和第15天以及此后每5周，给予3.5mg/m²的MMC与100ml生理盐水静脉滴注60分钟。6例患者共接受了24个疗程的治疗，这为初步探索该方法的疗效和毒性提供了机会。所有患者对这种治疗策略均表现出合理的耐受性。无因毒性导致的死亡病例。在经过精心挑选的患者群体中，CPT-11和MMC化疗可用于老年日本妇科恶性肿瘤患者。需要进行I期和II期研究以证实这种治疗方法的可行性。
