实验性变应性神经炎血清对正常大鼠周围神经的作用

Effect of experimental allergic neuritis serum on normal rat peripheral nerve.

作者信息

Rosen J L, Brown M J, Rostami A

机构信息

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.

出版信息

Pathobiology. 1990;58(2):95-8. doi: 10.1159/000163570.

DOI:10.1159/000163570

PMID:1694436

Abstract

To study the possible in vivo activity of experimental allergic neuritis (EAN) serum, we injected serum from rats immunized with whole nerve, P2 protein or adjuvant alone into the sciatic nerve of normal Lewis rats. Serum from whole nerve and P2-immunized animals produced demyelination 24 h after injection. Only high-titer anti-P2 serum was active and no control serum had this effect. Anti-P2 antibodies or other serum factors may contribute to the pathogenesis of whole nerve and P2-induced EAN.

摘要

为研究实验性变应性神经炎（EAN）血清可能的体内活性，我们将用全神经、P2蛋白或单独佐剂免疫的大鼠血清注射到正常Lewis大鼠的坐骨神经中。全神经和P2免疫动物的血清在注射后24小时产生脱髓鞘。只有高滴度抗P2血清具有活性，对照血清无此作用。抗P2抗体或其他血清因子可能参与全神经和P2诱导的EAN的发病机制。