一个用于预测蛋白质中B细胞和T细胞表位的基本微型计算机程序。
A BASIC microcomputer program for prediction of B and T cell epitopes in proteins.
作者信息
Menéndez-Arias L, Rodríguez R
机构信息
Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
出版信息
Comput Appl Biosci. 1990 Apr;6(2):101-5. doi: 10.1093/bioinformatics/6.2.101.
A BASIC microcomputer program (EPIPLOT) has been developed for predicting B and T cell antigenic sites in proteins from their primary structures. The program calculates and plots flexibility, hydrophilicity and antigenicity profiles using 13 different scales, chosen as those yielding the best predictions on proteins whose antigenic structures are known. T cell epitope prediction is based on published algorithms focused on amphiphilic structures and characteristic sequence patterns. The advantages of joint predictions in locating T cell antigenic sites are also discussed.
已开发出一个BASIC微机程序（EPIPLOT），用于从蛋白质的一级结构预测其B细胞和T细胞抗原位点。该程序使用13种不同的量表来计算和绘制柔韧性、亲水性和抗原性图谱，这些量表是从对已知抗原结构的蛋白质预测效果最佳的量表中挑选出来的。T细胞表位预测基于已发表的专注于两亲性结构和特征序列模式的算法。还讨论了联合预测在定位T细胞抗原位点方面的优势。
Zotero 插件