Bhogal Nirmala, Combes Robert
FRAME, 96-98 North Sherwood Street, Nottingham, NG1 4EE, UK.
Altern Lab Anim. 2006 Aug;34(4):429-54. doi: 10.1177/026119290603400401.
The impetus to develop useful models of human disease and toxicity has resulted in a number of large-scale mouse mutagenesis programmes. This, in turn, has stimulated considerable concern regarding the scientific validity and welfare of genetically altered mice, and the large numbers of mice that are required by such programmes. In this paper, the scientific advantages and limitations of genetically altered mice as models of several human diseases are discussed. We conclude that, while the use of some such mouse models has contributed considerably to an understanding of human disease and toxicity, other genetically altered mouse models have limited scientific relevance, and fewer have positively contributed to the development of novel human medicines. Suggestions for improving this unsatisfactory situation are made.
开发人类疾病和毒性有用模型的动力催生了一些大规模的小鼠诱变计划。这反过来又引发了人们对基因改造小鼠的科学有效性、福利以及此类计划所需大量小鼠的极大关注。本文讨论了基因改造小鼠作为几种人类疾病模型的科学优势和局限性。我们得出的结论是，虽然使用某些此类小鼠模型对理解人类疾病和毒性有很大贡献，但其他基因改造小鼠模型的科学相关性有限，对新型人类药物开发有积极贡献的则更少。文中还提出了改善这种不尽人意状况的建议。
