疫霉基因组序列揭示了其进化起源和致病机制。
Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis.
作者信息
Tyler Brett M, Tripathy Sucheta, Zhang Xuemin, Dehal Paramvir, Jiang Rays H Y, Aerts Andrea, Arredondo Felipe D, Baxter Laura, Bensasson Douda, Beynon Jim L, Chapman Jarrod, Damasceno Cynthia M B, Dorrance Anne E, Dou Daolong, Dickerman Allan W, Dubchak Inna L, Garbelotto Matteo, Gijzen Mark, Gordon Stuart G, Govers Francine, Grunwald Niklaus J, Huang Wayne, Ivors Kelly L, Jones Richard W, Kamoun Sophien, Krampis Konstantinos, Lamour Kurt H, Lee Mi-Kyung, McDonald W Hayes, Medina Mónica, Meijer Harold J G, Nordberg Eric K, Maclean Donald J, Ospina-Giraldo Manuel D, Morris Paul F, Phuntumart Vipaporn, Putnam Nicholas H, Rash Sam, Rose Jocelyn K C, Sakihama Yasuko, Salamov Asaf A, Savidor Alon, Scheuring Chantel F, Smith Brian M, Sobral Bruno W S, Terry Astrid, Torto-Alalibo Trudy A, Win Joe, Xu Zhanyou, Zhang Hongbin, Grigoriev Igor V, Rokhsar Daniel S, Boore Jeffrey L
机构信息
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
出版信息
Science. 2006 Sep 1;313(5791):1261-6. doi: 10.1126/science.1128796.
Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these Phytophthora species share the kingdom Stramenopila with photosynthetic algae such as diatoms, and the presence of many Phytophthora genes of probable phototroph origin supports a photosynthetic ancestry for the stramenopiles. Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes.
已测定了大豆病原体大豆疫霉和橡树猝死病原体恶疫霉的基因组序列草图。这些疫霉属的卵菌与硅藻等光合藻类同属不等鞭毛生物界，许多可能起源于光合生物的疫霉基因的存在支持了不等鞭毛生物具有光合祖先的观点。对这两个物种基因组的比较揭示了许多与植物感染相关的蛋白质家族的快速扩张和多样化，如水解酶、ABC转运蛋白、蛋白质毒素、蛋白酶抑制剂，尤其是一个由700种蛋白质组成的超家族，它们与已知的卵菌无毒基因相似。
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