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胰岛素样生长因子信号通路抑制剂：一种乳腺癌治疗方法

Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer.

作者信息

Sachdev Deepali, Yee Douglas

机构信息

Department of Medicine and Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St, SE, Minneapolis, MN 55455, USA.

出版信息

J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):27-39. doi: 10.1007/s10911-006-9010-8.

DOI:10.1007/s10911-006-9010-8
PMID:16947084
Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

摘要

肽生长因子IGF-I和IGF-II不仅在乳腺发育中起作用，还与乳腺癌有关。已经开发了几种破坏IGF信号传导的试剂，并且正在进行将IGF信号传导作为癌症治疗靶点进行验证的临床试验。这篇综述重点介绍了在乳腺癌中抑制IGF信号传导的方法。

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影响雌激素受体结合及活性的非编码单核苷酸变异体
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Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.蛋白质组学筛选与套索回归揭示胰岛素和胰岛素样生长因子I（IGF1）信号通路的差异
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