Yanagisawa A, Yotsumoto K, Kitagawa T, Sugano H, Kato Y
Department of Pathology, Cancer Institute, Tokyo.
Jpn J Cancer Res. 1990 Apr;81(4):372-5. doi: 10.1111/j.1349-7006.1990.tb02577.x.
Mucin-histochemical characteristics of normal human colorectal mucosa were investigated utilizing Culling et al.'s staining method which distinguishes the mode of C8-O-acylation of sialomucins. Normal mucosae of cecum, ascending, transverse and descending colon and rectum were obtained from autopsy and biopsy material. Japanese colorectal mucosa stained either entirely red or entirely blue, in contrast to previous reports dealing with Caucasians where all the normal mucosa reportedly stained red. The ratio of red to blue colon cases varied to some extent with age, i.e. it was found to be 1:1 in children aged 0 to 4, 2:1 in the 5-20 age group, and 4:1 in people older than 21 years, suggesting a tendency of shift from blue to red during early life in Japan. Each individual Japanese adult colorectal mucosa may thus be classified into either red or blue type mucin-histochemically.
利用卡林等人的染色方法对正常人结肠直肠黏膜的黏蛋白组织化学特征进行了研究，该方法可区分唾液黏蛋白的C8 - O - 酰化模式。盲肠、升结肠、横结肠、降结肠和直肠的正常黏膜取自尸检和活检材料。与之前关于白种人的报道不同，日本结肠直肠黏膜要么全染成红色，要么全染成蓝色，据报道白种人的所有正常黏膜均染成红色。红色与蓝色结肠病例的比例在一定程度上随年龄变化，即0至4岁儿童中该比例为1:1，5至20岁年龄组中为2:1，21岁以上人群中为4:1，这表明在日本，早期生活中存在从蓝色向红色转变的趋势。因此，每个日本成年结肠直肠黏膜在黏蛋白组织化学上可分为红色或蓝色类型。
