Nakamura Reo, Ito Kazuki, Koide Masahiro, Taniguchi Takuya, Irie Hidekazu, Kinoshita Noriyuki, Sawada Takahisa, Azuma Akihiro, Matsubara Hiroaki
Department of Cardiology, Kouseikai Takeda Hospital, Kyoto.
J Cardiol. 2006 Aug;48(2):85-92.
This study investigated the tissue characterization of human coronary artery plaque using Virtual Histology intravascular ultrasound (VH-IVUS) and temperature guide wire.
Between August 2005 and December 2005, VH-IVUS examination and guide wire based measurement of coronary temperature were performed in 66 patients: 39 with stable angina pectoris (SAP), and 27 with unstable angina pectoris(UAP). Patients in the acute myocardial infarction with necrotic tissue and thrombus were excluded. After measurement of distal coronary pressure and coronary temperature, the following tissue types of atherosclerotic plaque were evaluated by VH-IVUS: fibrotic, fibro-fatty, dense calcium and necrotic core. Occurrence of fibro-fatty tissue was significantly higher in UAP patients than in SAP patients (17.4 +/- 7.0% vs 11.2 +/- 5.2%, p = 0.04), and coronary temperature was significantly higher in UAP patients than in SAP patients (0.08 +/- 0.05 vs 0.03 +/- 0.02 degrees C, p = 0.01).
These results suggest that the combination of VH-IVUS analysis and measurement of coronary temperature may be able to predict the progression of lesions.
本研究采用虚拟组织学血管内超声（VH-IVUS）和温度导丝研究人类冠状动脉斑块的组织特征。
2005年8月至2005年12月期间，对66例患者进行了VH-IVUS检查和基于导丝的冠状动脉温度测量：39例稳定型心绞痛（SAP）患者和27例不稳定型心绞痛（UAP）患者。排除急性心肌梗死伴有坏死组织和血栓的患者。在测量冠状动脉远端压力和冠状动脉温度后，通过VH-IVUS评估以下类型的动脉粥样硬化斑块：纤维化、纤维脂肪、致密钙化和坏死核心。UAP患者中纤维脂肪组织的发生率显著高于SAP患者（17.4±7.0%对11.2±5.2%，p = 0.04），UAP患者的冠状动脉温度显著高于SAP患者（0.08±0.05对0.03±0.02℃，p = 0.01）。
这些结果表明，VH-IVUS分析和冠状动脉温度测量相结合可能能够预测病变的进展。
