Pypendop Bruno H, Pascoe Peter J, Ilkiw Jan E
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Am J Vet Res. 2006 Sep;67(9):1471-5. doi: 10.2460/ajvr.67.9.1471.
To determine effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats. Animals-6 healthy adult domestic shorthair cats.
Cats were anesthetized with isoflurane in oxygen. Morphine (100 microg/kg diluted with saline [0.9% NaCl] solution to a volume of 0.3 mL/kg), buprenorphine (12.5 microg/kg diluted with saline solution to a volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. The minimum alveolar concentration (MAC) of isoflurane was measured in triplicate by use of the tail clamp technique. At least 1 week was allowed between successive experiments.
The MAC of isoflurane was 2.00 +/- 0.18%, 2.13 +/- 0.11%, and 2.03 +/- 0.09% in the morphine, buprenorphine, and saline solution groups, respectively. No significant difference in MAC was detected among treatment groups.
A significant effect of epidural administration of morphine or buprenorphine on the MAC of isoflurane in cats could not be detected. Further studies are needed to establish whether epidural opioid administration has other benefits when administered as a component of general anesthesia in cats.
确定硬膜外给予吗啡和丁丙诺啡对猫异氟烷最低肺泡浓度的影响。动物——6只健康成年家养短毛猫。
猫在氧气中用异氟烷麻醉。根据拉丁方设计，将吗啡（100微克/千克用生理盐水[0.9%氯化钠]溶液稀释至0.3毫升/千克体积）、丁丙诺啡（12.5微克/千克用生理盐水溶液稀释至0.3毫升/千克体积）或生理盐水溶液（0.3毫升/千克）注入硬膜外腔。采用尾夹技术重复测量3次异氟烷的最低肺泡浓度（MAC）。连续实验之间至少间隔1周。
吗啡组、丁丙诺啡组和生理盐水溶液组异氟烷的MAC分别为2.00±0.18%、2.13±0.11%和2.03±0.09%。各治疗组之间未检测到MAC有显著差异。
未检测到硬膜外给予吗啡或丁丙诺啡对猫异氟烷MAC有显著影响。需要进一步研究以确定硬膜外给予阿片类药物作为猫全身麻醉的一部分时是否有其他益处。
