Waldmeier P, Hedwal P R, Maître L
Naunyn Schmiedebergs Arch Pharmacol. 1975;289(3):303-14. doi: 10.1007/BF00499983.
In renal hypertensive rats the cerebral concentration of alpha-methyldopa, alpha-methyldopamine, alpha-methylnoradrenaline, dopamine and noradrenaline as well as the blood-pressure were determined simultaneously. The antihypertensive effect followed a time course identical to that of the increase in the cerebral concentration of alpha-methyldopamine and of the decrease in the concentration of dopamine, whereas lowering of blood pressure on the one hand, and changes in the levels of alpha-methylnoradrenaline and noradrenaline, on the other, were not related to each other. Dose-response relationships showed the same correlations and lack of correlations, respectively. These results suggest that non-betat-hydroxylated catecholamines play a major role in mediating the antihypertensive effect of alpha-methyldopa or, alternatively, that only the newly biosynthesized alpha-methyl-noradrenaline is effective in lowering blood pressure.
在肾性高血压大鼠中，同时测定了脑内α-甲基多巴、α-甲基多巴胺、α-甲基去甲肾上腺素、多巴胺和去甲肾上腺素的浓度以及血压。降压作用的时间进程与脑内α-甲基多巴胺浓度的增加和多巴胺浓度的降低相同，而血压的降低一方面与α-甲基去甲肾上腺素和去甲肾上腺素水平的变化另一方面并无关联。剂量-反应关系分别显示出相同的相关性和缺乏相关性。这些结果表明，非β-羟化儿茶酚胺在介导α-甲基多巴的降压作用中起主要作用，或者说，只有新合成的α-甲基去甲肾上腺素在降低血压方面有效。
