Suppr超能文献

前臂体积描记法在评估血管张力和阻力血管系统设计中的应用:新的方法学见解

Forearm plethysmography in the assessment of vascular tone and resistance vasculature design: new methodological insights.

作者信息

Mathiassen O N, Buus N H, Olsen H W, Larsen M L, Mulvany M J, Christensen K L

机构信息

Department of Pharmacology, University of Aarhus, Aarhus C, Denmark.

出版信息

Acta Physiol (Oxf). 2006 Oct;188(2):91-101. doi: 10.1111/j.1748-1716.2006.01611.x.

Abstract

AIM

High peripheral resistance and structural alteration in resistance arteries are central phenomena in essential hypertension and have been widely examined by forearm venous occlusion plethysmography; at rest for studying vascular tone, and during reactive hyperaemia for studying vascular structure. This work concerns the influence of venous pressure on hyperaemic vascular resistance (Rmin), the reproducibility of hyperaemic and resting vascular resistances (Rrest) and the relation between forearm and total peripheral vascular resistance (TPR).

METHODS

In four healthy subjects, intravenous and intra-arterial blood pressures were measured simultaneously with plethysmographic recordings of hyperaemic and resting forearm blood flows. Reproducibility was examined in 15 young and 14 middle-aged healthy subjects and in 21 untreated hypertensive patients.

RESULTS

Rmin remained low in the first recorded cardiac cycle, but rose in the second, even though corrected for the venous pressure rise, suggesting vascular tone recovery along with venous congestion. Between-day reproducibility of Rmin was high in middle-aged normotensive (8.7%) and hypertensive subjects (10.6%), but Rmin fell significantly between successive days in the young subjects. Rrest correlated with TPR, but required up to 40 min to reach steady state and showed high day-to-day variation in young (21.8%) and hypertensive subjects (16.2%).

CONCLUSIONS

During hyperaemia, vascular resistance should be measured in the first cardiac cycle following venous occlusion to minimize influences of venous pressure rise and possible tone recovery. Rrest seems to reflect TPR. About 20 subjects may be needed to detect 15% changes between days in Rrest, fewer when concerning Rmin and TPR.

摘要

目的

外周阻力增高以及阻力动脉结构改变是原发性高血压的核心现象,已通过前臂静脉阻塞体积描记法进行了广泛研究;静息时用于研究血管张力,反应性充血期间用于研究血管结构。本研究关注静脉压对充血性血管阻力(Rmin)的影响、充血性和静息性血管阻力(Rrest)的可重复性以及前臂与总外周血管阻力(TPR)之间的关系。

方法

对4名健康受试者同时测量静脉压和动脉压,并通过体积描记法记录充血和静息时的前臂血流。在15名年轻和14名中年健康受试者以及21名未经治疗的高血压患者中检查了可重复性。

结果

在第一个记录的心动周期中,Rmin保持较低水平,但在第二个心动周期中升高,即使校正了静脉压升高,这表明血管张力随着静脉充血而恢复。中年血压正常者(8.7%)和高血压患者(10.6%)中,Rmin的日间可重复性较高,但年轻受试者连续几天之间Rmin显著下降。Rrest与TPR相关,但需要长达40分钟才能达到稳态,并且在年轻受试者(21.8%)和高血压患者(16.2%)中表现出较高的日间变化。

结论

在充血期间,应在静脉阻塞后的第一个心动周期测量血管阻力,以尽量减少静脉压升高和可能的张力恢复的影响。Rrest似乎反映了TPR。检测Rrest日间15%的变化可能需要约20名受试者,检测Rmin和TPR变化时所需受试者较少。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验