Biedzka-Sarek Marta, El Skurnik Mika
Department of Bacteriology and Immunology, Haartman Institute, 00014 University of Helsinki, Helsinki, Finland.
APMIS. 2006 Sep;114(9):589-600. doi: 10.1111/j.1600-0463.2006.apm_465.x.
Salmonella enterica serovar Typhi causes typhoid fever, a serious life-threatening systemic infection. In mice, a similar disease is caused by Salmonella enterica serovar Typhimurium. During typhoid fever, soon after attachment to the mucosal surface of the gut, bacteria come into contact with the dendritic cells (DCs). The ability to sample antigens, process and present them to naïve and mature T cells, in the context of major histocompatibility complex molecules, makes DCs indispensable for mounting a specific and efficient immune response to invading pathogens. These bacteria, however, have evolved a number of mechanisms to interfere with or subvert DC functions. This review aims to describe how Salmonella clashes with dendritic cells at different stages of infection as well as the war strategies of these two opposing sides.
肠炎沙门氏菌伤寒血清型可引发伤寒热，这是一种严重的、危及生命的全身性感染。在小鼠中，类似的疾病由肠炎沙门氏菌鼠伤寒血清型引起。在伤寒热期间，细菌附着于肠道黏膜表面后不久，就会与树突状细胞（DCs）接触。在主要组织相容性复合体分子的背景下，树突状细胞具有摄取抗原、加工并将其呈递给幼稚和成熟T细胞的能力，这使得树突状细胞对于针对入侵病原体产生特异性和高效的免疫反应不可或缺。然而，这些细菌已经进化出多种机制来干扰或颠覆树突状细胞的功能。本综述旨在描述沙门氏菌在感染的不同阶段如何与树突状细胞发生冲突，以及这两个对立阵营的战争策略。
