[The value of a study of the microvascularization and the cellular immunosurveillance of precancerous states and micro-cancers of the oral cavity].

In 35 patients with leukoplakia or erythroplastic lesions of oral mucosa, the immunohistochemical study of Langerhans cells and various types of lymphocytes demonstrated increasing changes in cellular immunoreactivity in benign leukokeratosis, dysplasia and in situ or microinvasive carcinoma. Besides, the study of alkaline phosphatase activity by means of histoenzymological methods proved an intense angiogenesis during the occurrence of cancerization.