用小RNA调节外膜。

Modulating the outer membrane with small RNAs.

作者信息

Guillier Maude, Gottesman Susan, Storz Gisela

机构信息

Laboratory of Molecular Biology, National Cancer Institute, Bethesda 20892, Maryland, USA.

出版信息

Genes Dev. 2006 Sep 1;20(17):2338-48. doi: 10.1101/gad.1457506.

DOI:10.1101/gad.1457506

PMID:16951250

Abstract

MicF, one of the first chromosomally encoded regulatory small RNAs (sRNAs) to be discovered, was found to modulate the expression of OmpF, an abundant outer membrane protein. Several recent papers have now shown that this is not an isolated case. At least five other sRNAs also regulate the synthesis of outer membrane porins, and additional sRNAs modulate the expression of other outer membrane proteins. Here we review what is known about these sRNAs and discuss the implications of this regulation.

摘要

MicF是最早发现的由染色体编码的调控性小RNA（sRNA）之一，它被发现可调节外膜蛋白OmpF的表达。最近的几篇论文表明，这并非个例。至少还有其他五种sRNA也调节外膜孔蛋白的合成，另外还有一些sRNA调节其他外膜蛋白的表达。在此，我们综述关于这些sRNA的已知信息，并讨论这种调控的意义。