Zduńczyk A, Miszta H, Dabrowski Z
Clinic of Haematology, Medical Academy Cracow, Poland.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(1):51-8.
The effect of recombinant alpha interferon (INF) and of antilymphocyte globulin (ALG) to the colony stimulating factor (CSF) production was examined with in vitro culture of the bone marrow of healthy and of aplastic anaemia (AA) persons. In healthy persons the supernatant of lymphocytes preincubated with PHA and ALG was found to show a stimulating effect to clonogenic properties of marrow progenitors, the mentioned effect being not in proportion to the concentration value. Similar properties are shown by interferon in these persons. In patients with aplastic anaemia, a considerable stimulating ALG effect to the granulocytic formation of colonies and a lesser stimulating effect of interferon were shown.
通过对健康人和再生障碍性贫血（AA）患者的骨髓进行体外培养，研究了重组α干扰素（INF）和抗淋巴细胞球蛋白（ALG）对集落刺激因子（CSF）产生的影响。在健康人中，发现用PHA和ALG预孵育的淋巴细胞上清液对骨髓祖细胞的克隆形成特性有刺激作用，上述作用与浓度值不成比例。在这些人中，干扰素也表现出类似特性。在再生障碍性贫血患者中，显示出ALG对粒细胞集落形成有相当大的刺激作用，而干扰素的刺激作用较小。
