重组人α干扰素（INF）对慢性粒细胞白血病（CGL）骨髓造血祖细胞克隆生长的影响。
Effect of recombinant human alpha interferon (INF) on chronic granulocytic leukaemia (CGL) clonogenic growth of bone marrow haematopoietic progenitors.
作者信息
Zduńczyk A, Miszta H, Dabrowski Z
机构信息
Clinic of Haematology, Medical Academy Cracow, Poland.
出版信息
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(1):45-50.
PMID:1695182
Abstract
The effect of recombinant alpha interferon (INF) to the colony stimulating factor (CSF) production was examined with in vitro culture of the bone marrow of patients with chronic granulocytic leukaemia (CGL). It could be found that addition of interferon into a suspension of preincubated phytohaemagglutinin (PHA) lymphocytes from peripheral blood represents an inhibity factor for colony and cluster formation in autologic human marrow cultures.
摘要
采用慢性粒细胞白血病（CGL）患者骨髓进行体外培养，研究重组α干扰素（INF）对集落刺激因子（CSF）产生的影响。结果发现，向预先孵育的外周血植物血凝素（PHA）淋巴细胞悬液中添加干扰素，对自体人骨髓培养中的集落和集簇形成具有抑制作用。
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