Inoki R
Department of Pharmacology, Faculty of Dentistry, Osaka University, Japan.
Nihon Yakurigaku Zasshi. 1990 Apr;95(4):139-47. doi: 10.1254/fpj.95.4_139.
This review describes: recent findings about the peripheral site of action and mechanism of the algesic action of narcotic and nonnarcotic analgesics. Special attention was given to the stimulatory or inhibitory actions of opiates and opioid peptides on the polymodal receptor of the sensory afferent fibers. Bradykinin, a pain producing substance, augmented the production of opioid peptides, for example, methionine and leucine enkephalins in in vitro and in vivo experiments. It was demonstrated that a pharmacological feed back reaction, the antinociceptive response, took place in the peripheral site of the primary afferent fibers.
关于麻醉性和非麻醉性镇痛药的外周作用部位及痛觉作用机制的最新研究结果。特别关注了阿片类药物和阿片肽对感觉传入纤维多模式受体的刺激或抑制作用。缓激肽，一种致痛物质，在体外和体内实验中增强了阿片肽的产生，例如甲硫氨酸脑啡肽和亮氨酸脑啡肽。结果表明，在初级传入纤维的外周部位发生了一种药理反馈反应，即抗伤害感受反应。
