Watanabe Kenta, Kondo Kenji, Takeuchi Naonobu, Nibu Ken-ichi, Kaga Kimitaka
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Brain Res. 2006 Oct 20;1116(1):82-92. doi: 10.1016/j.brainres.2006.07.124. Epub 2006 Sep 6.
We investigated age-related changes in the distribution and proliferation of olfactory ensheathing cells (OECs) in postnatal mouse olfactory mucosa. In contrast to reported data on other glial cell types in the peripheral and central nervous systems, OEC cell density in the olfactory nerve bundles in the lamina propria remained almost constant from 10 days through 16 months of age. Electron microscopy of the nerve bundles revealed that axon packing density also was constant during that period. These findings suggest that the ratio of the number of OECs to the unit length of the olfactory neuron axons ensheathed by them does not change markedly throughout the lifetime of mice in an undisturbed condition. By contrast, OEC proliferative density decreased rapidly in the 10-day to 1-month-old period, showing a significant difference, and for the rest of life remained at low level, similar to previous values reported for other glial cell types.
我们研究了出生后小鼠嗅黏膜中嗅鞘细胞（OECs）分布和增殖的年龄相关变化。与关于外周和中枢神经系统中其他胶质细胞类型的报道数据相反，从10天到16个月龄，固有层嗅神经束中的OEC细胞密度几乎保持恒定。神经束的电子显微镜检查显示，在此期间轴突堆积密度也保持恒定。这些发现表明，在未受干扰的情况下，小鼠一生中，OECs数量与它们所包裹的嗅神经元轴突单位长度的比例没有明显变化。相比之下，OEC增殖密度在10天至1个月龄期间迅速下降，显示出显著差异，并且在生命的其余时间保持在低水平，与先前报道的其他胶质细胞类型的值相似。
