Wang Zhiqiang, Hoy Wendy E
Centre for Chronic Disease, School of Medicine, The University of Queensland, Level H, Clinical Sciences Building, Royal Brisbane Hospital Brisbane, Herston, Qld 4029, Australia.
Diabetes Res Clin Pract. 2007 Apr;76(1):37-43. doi: 10.1016/j.diabres.2006.07.018. Epub 2006 Sep 6.
To investigate the association between C-reactive protein (CRP) and the risk of developing diabetes in Aboriginal Australians.
High sensitivity CRP levels were measured in 620 Aboriginal participants aged 20-74 years free from diabetes at baseline in a remote community in the Northern Territory of Australia. Participants were followed for a median of 11 years to identify newly diagnosed cases of diabetes. Cox proportional hazards models were used to assess the relationship of CRP levels with the risk of developing diabetes over the follow-up period.
A total of 109 participants were newly diagnosed with diabetes. Incident rates were 10.8, 16.6 and 28.8 per 1000 person-years for people in the lower, middle and upper tertile groups of baseline CRP levels, respectively. After adjusting for age, sex, BMI, baseline glucose regulation status, total cholesterol, urine albumin to creatinine ratio, systolic blood pressure, smoking and alcohol drinking, the association between diabetes and CRP remained significant, with a hazard ratio of 1.23 (95% confidence interval (CI) 1.05, 1.45) corresponding to a doubling in CRP values. Similarly, the adjusted hazard ratio for development of diabetes in people in the upper tertile versus the bottom two tertiles of CRP was 1.75 (95% CI 1.19, 2.56).
CRP is independently associated with the development of diabetes in Aboriginal people. Our findings support a role of inflammation in the etiology of diabetes in the high risk population of Aboriginal Australians.
研究澳大利亚原住民中C反应蛋白(CRP)与患糖尿病风险之间的关联。
在澳大利亚北领地一个偏远社区,对620名年龄在20 - 74岁、基线时无糖尿病的原住民参与者测量了高敏CRP水平。对参与者进行了为期11年的随访,以确定新诊断的糖尿病病例。采用Cox比例风险模型评估随访期间CRP水平与患糖尿病风险的关系。
共有109名参与者新诊断为糖尿病。基线CRP水平处于低、中、高三分位组的人群,其发病率分别为每1000人年10.8、16.6和28.8例。在调整了年龄、性别、体重指数、基线血糖调节状态、总胆固醇、尿白蛋白与肌酐比值、收缩压、吸烟和饮酒因素后,糖尿病与CRP之间的关联仍然显著,风险比为1.23(95%置信区间(CI)1.05,1.45),对应CRP值翻倍。同样,CRP处于高三分位组的人群与低二分位组人群相比,患糖尿病的调整后风险比为1.75(95% CI 1.19,2.56)。
CRP与澳大利亚原住民患糖尿病独立相关。我们的研究结果支持炎症在澳大利亚原住民这一高危人群糖尿病病因学中的作用。