Cantor A, Cristal N
Rehabilitation Service, Soroka Medical Center, Beer Sheva, Israel.
J Cardiovasc Pharmacol. 1990;15 Suppl 1:S76-8.
The objectives of this study were (a) to evaluate the dose-response effect of isradipine, a dihydropyridine calcium antagonist, on the heart rate and blood pressure of males with mild to moderate hypertension; and (b) to compare these results with those obtained with propranolol, a beta-adrenoceptor blocker, on a matched patient population. Twenty-four patients entered a single-blind study, beginning with a 2-week washout placebo period followed by a forced-titration period. Treadmill and hand-grip tests were also performed. Two weeks were allocated to each stage of the therapy. The end point of the study was normalization of blood pressure with a minimum of side effects. Results and conclusions include the following: both drugs were effective in reducing systolic blood pressure (SBP) and diastolic blood pressure (DBP), but isradipine was more effective in reducing the DBP; isometric exercise can predict accurately the results of the isotonic exercise; the maximum therapeutic effect of propranolol was achieved during the second study-dose level; increases in the isradipine dose were reflected in a proportional reduction of SBP and DBP; and the incidence of side effects is lower among isradipine-treated patients compared to propranolol-treated patients.
（a）评估二氢吡啶类钙拮抗剂伊拉地平对轻至中度高血压男性患者心率和血压的剂量反应效应；（b）在匹配的患者群体中，将这些结果与β肾上腺素能受体阻滞剂普萘洛尔所获得的结果进行比较。24名患者进入一项单盲研究，首先是为期2周的洗脱期，期间服用安慰剂，随后是强制滴定期。还进行了跑步机和握力测试。每个治疗阶段分配两周时间。研究的终点是血压正常化且副作用最小。结果与结论如下：两种药物均能有效降低收缩压（SBP）和舒张压（DBP），但伊拉地平在降低DBP方面更有效；等长运动能够准确预测等张运动的结果；普萘洛尔在第二个研究剂量水平时达到最大治疗效果；伊拉地平剂量增加会使SBP和DBP成比例降低；与普萘洛尔治疗的患者相比，伊拉地平治疗的患者副作用发生率更低。
