Wood Ian A, Moser Gerhard, Burrell Daniel L, Mengersen Kerrie L, Hetzel D Jay S
School of Mathematical Sciences, Queensland University of Technology, GPO Box 2434 Brisbane, QLD 4001, Australia.
Genet Sel Evol. 2006 Sep-Oct;38(5):479-94. doi: 10.1186/1297-9686-38-5-479. Epub 2006 Sep 6.
A meta-analysis was undertaken reporting on the association between a polymorphism in the Thyroglobulin gene (TG5) and marbling in beef cattle. A Bayesian hierarchical model was adopted, with alternative representations assessed through sensitivity analysis. Based on the overall posterior means and posterior probabilities, there is substantial support for an additive association between the TG5 marker and marbling. The marker effect was also assessed across various breed groups, with each group displaying a high probability of positive association between the T allele and marbling. The WinBUGS program code used to simulate the model is included as an Appendix available online at www.edpsciences.org/gse.
进行了一项荟萃分析,报告甲状腺球蛋白基因(TG5)中的多态性与肉牛大理石花纹之间的关联。采用了贝叶斯层次模型,并通过敏感性分析评估了替代表示形式。基于总体后验均值和后验概率,有大量证据支持TG5标记与大理石花纹之间存在加性关联。还对不同品种组的标记效应进行了评估,每个组中T等位基因与大理石花纹之间呈正相关的概率都很高。用于模拟该模型的WinBUGS程序代码作为附录包含在www.edpsciences.org/gse上的在线资源中。