Taylor Roger E
Clinical Oncology, South West Wales Cancer Institute, Singleton Hospital, Swansea, West Glamorgan, SA2 8QA, UK.
Eur J Paediatr Neurol. 2006 Jul;10(4):167-75. doi: 10.1016/j.ejpn.2006.07.006. Epub 2006 Sep 6.
This review summarises current developments in radiation oncology and how they impact on the management of children with brain tumours. Improved understanding of radiobiology has led to attempts to improve the therapeutic ratio with hyperfractionated radiotherapy. Recent advances in planning and delivery of radiotherapy, including three-dimensional conformal radiotherapy, intensity modulated radiotherapy, and proton therapy allow a more precise localisation of the maximum dose region with maximum sparing of normal brain. Increasingly interactions between drugs and radiotherapy are exploited, but it is important to evaluate toxicity of combined modality therapy. The introduction of models to predict the impact of radiotherapy dose-volume parameters on long-term neuropsychological function will hopefully lead to further benefit with respect to sparing of normal tissue morbidity.
本综述总结了放射肿瘤学的当前进展及其对儿童脑肿瘤治疗的影响。对放射生物学更深入的理解促使人们尝试通过超分割放疗提高治疗增益比。放疗计划和实施方面的最新进展，包括三维适形放疗、调强放疗和质子治疗，能够更精确地定位最大剂量区域，同时最大程度地减少对正常脑组织的照射。药物与放疗之间的相互作用越来越多地得到利用，但评估联合治疗模式的毒性很重要。引入预测放疗剂量 - 体积参数对长期神经心理功能影响的模型，有望在减少正常组织并发症方面带来更多益处。
