Grosman N, Nielsen J K
Department of Pharmacology, University of Copenhagen, Denmark.
Agents Actions. 1990 Apr;30(1-2):134-6. doi: 10.1007/BF01969019.
The effects of TMB-8 and calmidazolium were investigated on mast cell responses believed to be mediated by protein kinase C, i.e. histamine release induced by TPA (tetradecanoyl-phorbol-acetate) in combination with sub-threshold concentrations of the ionophore A23187 and with antigen. Inhibition with both drugs was found in the same concentration range as observed earlier and could be counteracted by glucose, indicating an impaired oxidative energy production. Hence, the test drugs do not reveal protein kinase C selectivity.
研究了TMB - 8和氯米帕明对认为由蛋白激酶C介导的肥大细胞反应的影响，即由佛波醇肉豆蔻酸酯乙酸酯（TPA）与亚阈值浓度的离子载体A23187以及抗原联合诱导的组胺释放。发现两种药物在与早期观察到的相同浓度范围内均有抑制作用，且可被葡萄糖抵消，这表明氧化能量产生受损。因此，受试药物未显示出蛋白激酶C选择性。
