Scott-Moncrieff J Catharine, Glickman Nita W, Glickman Lawrence T, HogenEsch Harm
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
J Vet Intern Med. 2006 Jul-Aug;20(4):818-21. doi: 10.1892/0891-6640(2006)20[818:loabrv]2.0.co;2.
Intensive vaccination protocols have been suggested as partially responsible for an increased prevalence of autoimmune diseases in dogs in recent years. The aim of this study was to determine whether repeated routine vaccination in dogs is associated with an increased prevalence of thyroiditis.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a prospective experimental study with 20 healthy purpose-bred Beagles. Five dogs were vaccinated with a multivalent vaccine and a rabies vaccine. Five dogs received only the multivalent vaccine, and 5 dogs received only the rabies vaccine. Five dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once a year. Blood samples were collected 1 week before euthanasia for evaluation of thyroid profiles and measurement of antibodies directed against canine thyroglobulin. Dogs were euthanized at 5.5 years of age, and the thyroid glands were evaluated histopathologically. Thyroiditis was present in 8 of 20 (40%) dogs at postmortem examination. No association was found between a dog being vaccinated and the prevalence of thyroiditis at postmortem examination. However, the power of the study to detect such an association was low because of the unexpected high prevalence of thyroiditis in the unvaccinated control dogs. Thyroid function tests were abnormal in 2 of 8 dogs with thyroiditis but were normal in all dogs without thyroiditis.
CONCLUSIONS/SIGNIFICANCE: There was no evidence to support an association between routine vaccination and thyroiditis at postmortem examination in beagle dogs after repeated vaccination.
近年来，强化疫苗接种方案被认为是犬类自身免疫性疾病患病率增加的部分原因。本研究的目的是确定犬类重复进行常规疫苗接种是否与甲状腺炎患病率增加有关。
方法/主要发现：我们对20只健康的纯种比格犬进行了一项前瞻性实验研究。5只犬接种了多价疫苗和狂犬病疫苗。5只犬仅接种了多价疫苗，5只犬仅接种了狂犬病疫苗。5只犬作为未接种疫苗的对照。多价疫苗在犬8、10、12、16、20、26和52周龄时接种，此后每6个月接种一次。狂犬病疫苗在犬16和52周龄时接种，然后每年接种一次。在安乐死1周前采集血样，以评估甲状腺指标并检测抗犬甲状腺球蛋白抗体。犬在5.5岁时安乐死，对甲状腺进行组织病理学评估。尸检时，20只犬中有8只（40%）患有甲状腺炎。在尸检时，未发现犬接种疫苗与甲状腺炎患病率之间存在关联。然而，由于未接种疫苗的对照犬中甲状腺炎患病率意外较高，该研究检测这种关联的能力较低。8只患有甲状腺炎的犬中有2只甲状腺功能测试异常，但所有无甲状腺炎的犬甲状腺功能测试均正常。
结论/意义：在重复接种疫苗后，没有证据支持比格犬尸检时常规疫苗接种与甲状腺炎之间存在关联。
