Bergmann Michèle, Freisl Monika, Hartmann Katrin, Speck Stephanie, Truyen Uwe, Zablotski Yury, Mayr Matthias, Wehner Astrid
Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany.
Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany.
Vaccines (Basel). 2021 Feb 20;9(2):180. doi: 10.3390/vaccines9020180.
(1) Background: No information is available on how dogs with hypothyroidism (HypoT) respond to vaccination. This study measured pre- and post-vaccination anti-canine parvovirus (CPV) antibodies in dogs with HypoT treated with levothyroxine and compared the results to those of healthy dogs. (2) Methods: Six dogs with HypoT and healthy age-matched control dogs (n = 23) were vaccinated against CPV with a modified-live vaccine. Hemagglutination inhibition was used to measure antibodies on days 0, 7, and 28. The comparison of the vaccination response of dogs with HypoT and healthy dogs were performed with univariate analysis. (3) Results: Pre-vaccination antibodies (≥10) were detected in 100% of dogs with HypoT (6/6; 95% CI: 55.7-100) and in 100% of healthy dogs (23/23; 95% CI: 83.1-100.0). A ≥4-fold titer increase was observed in none of the dogs with HypoT and in 4.3% of the healthy dogs (1/23; CI: <0.01-22.7). Mild vaccine-associated adverse events (VAAEs) were detected in 33.3% of the dogs with HypoT (2/6; 95% CI: 9.3-70.4) and in 43.5% (10/23; 95% CI: 25.6-63.2) of the healthy dogs. (4) Conclusions: There was neither a significant difference in the dogs' pre-vaccination antibodies ( = 1.000), or vaccination response ( = 0.735), nor in the occurrence of post-vaccination VAAEs ( = 0.798). The vaccination response in dogs with levothyroxine-treated HypoT seems to be similar to that of healthy dogs.
(1) 背景：关于甲状腺功能减退症（HypoT）犬只对疫苗接种的反应尚无相关信息。本研究测定了用左甲状腺素治疗的HypoT犬只接种犬细小病毒（CPV）疫苗前后的抗体，并将结果与健康犬只的结果进行比较。(2) 方法：6只患有HypoT的犬只和年龄匹配的健康对照犬只（n = 23）用改良活疫苗接种CPV疫苗。在第0、7和28天使用血凝抑制法测定抗体。对HypoT犬只和健康犬只的疫苗接种反应进行单因素分析比较。(3) 结果：100%的HypoT犬只（6/6；95%置信区间：55.7 - 100）和100%的健康犬只（23/23；95%置信区间：83.1 - 100.0）检测到接种前抗体（≥10）。在HypoT犬只中未观察到滴度升高≥4倍的情况，而在4.3%的健康犬只中观察到（1/23；置信区间：<0.01 - 22.7）。33.3%的HypoT犬只（2/6；95%置信区间：9.3 - 70.4）和43.5%（10/23；95%置信区间：25.6 - 63.2）的健康犬只检测到轻度疫苗相关不良事件（VAAEs）。(4) 结论：犬只接种前抗体（P = 1.000）、疫苗接种反应（P = 0.735）或接种后VAAEs的发生率（P = 0.798）均无显著差异。用左甲状腺素治疗的HypoT犬只的疫苗接种反应似乎与健康犬只相似。
