Sakallioglu O, Duzova A, Ozen S
Pediatric Nephrology and Rheumatology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Clin Exp Rheumatol. 2006 Jul-Aug;24(4):435-7.
Familial Mediterranean fever (FMF) patients may present with different joint complaints, one being the 'protracted attack' that lasts for weeks. We present a 15 year-old boy with polyarthritis (right wrist, knee, shoulder, and both ankles) while on colchicine treatment for FMF. His polyarthritis was resistant to treatment with prednisolone and methotrexate, and etanercept was instituted (0.8 mg/kg/week). He responded dramatically to etanercept and remained in full remission, although the drug was stopped at 4 months due to social and financial causes. We suggest that anti-TNF drugs may be an alternative for resistant attacks. However the timing and dosage, as well as efficacy, need to be further studied.
家族性地中海热（FMF）患者可能出现不同的关节症状，其中一种是持续数周的“迁延性发作”。我们报告一名15岁男孩，患有FMF，正在接受秋水仙碱治疗，出现了多关节炎（右腕、膝、肩和双踝）。他的多关节炎对泼尼松龙和甲氨蝶呤治疗无效，遂开始使用依那西普（0.8 mg/kg/周）。他对依那西普反应显著，一直处于完全缓解状态，不过由于社会和经济原因，该药物在4个月时停用。我们认为抗TNF药物可能是治疗难治性发作的一种选择。然而，其使用时机、剂量以及疗效仍需进一步研究。
