Berthelot Cindy, Zirwas Matthew J
University of Texas Medical School Southwestern, Dallas, TX, USA.
Dermatitis. 2006 Sep;17(3):156-9. doi: 10.2310/6620.2006.05057.
Chloroxylenol, also known as p-chloro-m-xylenol (PCMX), is a compound that has been used as a preservative in cosmetics and as an active agent in antimicrobial soaps. We present two patients with allergic contact dermatitis from PCMX, confirmed by positive (+++) patch-test reactions at 48 and 72 hours, identification of PCMX in a soap and in a hand cream used by the patients, and improvement following withdrawal of the incriminating products. The mechanism of action, structure, antimicrobial activity, and dangers of PCMX are reviewed.
对氯间二甲苯酚，也被称为对氯-间二甲苯酚（PCMX），是一种曾被用作化妆品防腐剂以及抗菌肥皂活性剂的化合物。我们报告了两例对PCMX过敏的接触性皮炎患者，通过48小时和72小时呈阳性（+++）的斑贴试验反应、在患者使用的肥皂和护手霜中鉴定出PCMX以及停用相关产品后症状改善得以确诊。本文还综述了PCMX的作用机制、结构、抗菌活性及危害。
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