Hong Soyoung, Kwon Ho-Jang, Choi Won-Jun, Lim Wan Ryung, Kim Jeonghoon, Kim KyooSang
Department of Environmental Health Research, Seoul Medical Center, Seoul, Korea ; Graduate School of Public Health, Seoul National University, Seoul, Korea.
Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea.
Environ Health Toxicol. 2014 Nov 21;29:e2014017. doi: 10.5620/eht.e2014017. eCollection 2014.
Antimicrobial chemicals are used in a variety of household and personal care products. Exposure to antimicrobial household products has been hypothesized to lead to allergic diseases in children.
We investigated antimicrobial household product exposure and allergic symptoms in Korean children. An antimicrobial exposure (AE) score was derived. To examine the symptoms of allergic diseases (current wheeze, current rhinitis, and current eczema) in the past 12 months, we used a questionnaire based on the core module of the International Study of Asthma and Allergies in Children. Complete data for the analysis were available for 25,805 of the 35,590 (72.5%) children.
The prevalence of current allergic diseases was as follows: wheeze, 5.6%; allergic rhinitis, 32.6%; and eczema, 17.7%. The mean (standard deviation) AE score was 14.3 (9.3) (range: 0-40). Compared with subjects with a low AE score (reference), subjects with a high AE score (fourth quartile) were more likely to have symptoms of wheezing and allergic rhinitis (adjusted odds ratio [aOR] for wheezing 1.24, 95% confidence interval [CI], 1.05-1.45, p for trend=0.24; aOR for allergic rhinitis 1.30, 95% CI, 1.20-1.40, p<0.01).
These findings suggest that frequent use of antimicrobial household products was associated with current wheeze and current allergic rhinitis.
抗菌化学品被用于多种家用和个人护理产品中。据推测，接触家用抗菌产品会导致儿童出现过敏性疾病。
我们调查了韩国儿童接触家用抗菌产品的情况以及过敏症状。得出了抗菌接触（AE）评分。为了调查过去12个月内过敏性疾病（当前喘息、当前鼻炎和当前湿疹）的症状，我们使用了基于儿童哮喘和过敏国际研究核心模块的问卷。在35590名儿童中，有25805名（72.5%）儿童可获得完整的分析数据。
当前过敏性疾病的患病率如下：喘息为5.6%；过敏性鼻炎为32.6%；湿疹为17.7%。平均（标准差）AE评分为14.3（9.3）（范围：0 - 40）。与低AE评分的受试者（参照）相比，高AE评分（第四四分位数）的受试者更有可能出现喘息和过敏性鼻炎症状（喘息的调整优势比[aOR]为1.24，95%置信区间[CI]为1.05 - 1.45，趋势p值 = 0.24；过敏性鼻炎的aOR为1.30，95%CI为1.20 - 1.40，p<0.01）。
这些发现表明，频繁使用家用抗菌产品与当前的喘息和当前的过敏性鼻炎有关。
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