正常、反应性和恶性浆细胞的表型。“多发性骨髓瘤”的鉴定及骨髓瘤治疗新靶点
The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy.
作者信息
Bataille Régis, Jégo Gaëtan, Robillard Nelly, Barillé-Nion Sophie, Harousseau Jean-Luc, Moreau Philippe, Amiot Martine, Pellat-Deceunynck Catherine
机构信息
INSERM, U601, Nantes, France.
出版信息
Haematologica. 2006 Sep;91(9):1234-40.
The aim of this review is to integrate non-exhaustive relevant data on the phenotype of human plasma cells (PC), including normal, reactive and malignant (multiple myeloma, MM) PC. This review focuses on (i) a universal marker of both normal and malignant plasma cells, CD138; (ii) markers related to malignancy i.e., CD19, CD27, CD28, and CD56; (iii) markers associated with signaling and severity of MM (CD45, CD221). Finally, this review presents data from normal PC up to human myeloma cell lines in order to: (i) define different entities of MM based on expression of CD19, CD20, CD27 and CD117; and (ii) identify new therapeutic targets.
本综述的目的是整合关于人浆细胞（PC）表型的非详尽相关数据，包括正常、反应性和恶性（多发性骨髓瘤，MM）浆细胞。本综述聚焦于：（i）正常和恶性浆细胞的通用标志物CD138；（ii）与恶性相关的标志物，即CD19、CD27、CD28和CD56；（iii）与MM信号传导和严重程度相关的标志物（CD45、CD221）。最后，本综述展示了从正常浆细胞到人类骨髓瘤细胞系的数据，以便：（i）基于CD19、CD20、CD27和CD117的表达定义MM的不同实体；（ii）识别新的治疗靶点。
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