Department of Gastroenterology, Sanda City Hospital, Hyogo, Japan.
Department of Hematology, Shinko Hospital, Hyogo, Japan.
J Clin Exp Hematop. 2024;64(1):65-70. doi: 10.3960/jslrt.23056.
A 79-year-old man presented with a history of solitary plasmacytoma in the bone 10 years ago. Chemoradiotherapy was effective, and remission was maintained with intermittent treatment at relapse of the bone lesions. One year after the last treatment, a follow-up computed tomography (CT) scan revealed multiple liver masses, and a liver biopsy revealed plasmacytoma. There was no clonal plasma cell infiltration in the bone marrow, and the final diagnosis was solitary plasmacytomas of the liver. Although liver involvement is known in relapsed refractory multiple myeloma, solitary plasmacytoma in the relapsed stage confined to the liver is rare, and all previous reports have been from the initial presentation. To the best of our knowledge, this is the first recurrent case of solitary plasmacytoma of the liver.
一位 79 岁男性，10 年前患有孤立性浆细胞瘤。化疗和放疗有效，在骨病变复发时间歇性治疗以维持缓解。最后一次治疗后 1 年，随访 CT 扫描显示多个肝肿块，肝活检显示浆细胞瘤。骨髓中无克隆性浆细胞浸润，最终诊断为肝孤立性浆细胞瘤。虽然在复发性难治性多发性骨髓瘤中已知有肝脏受累，但在复发期局限于肝脏的孤立性浆细胞瘤很少见，所有以前的报告均来自初始表现。据我们所知，这是首例复发性肝孤立性浆细胞瘤病例。
