自闭症的神经病理学和遗传学发现：一种假定的小柱病变的意义。

Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy.

作者信息

Casanova Manuel F

机构信息

Department of Psychiatry and Behavioral Sciences University of Louisville, 500 South Preston Street, Louisville, KY, USA.

出版信息

Neuroscientist. 2006 Oct;12(5):435-41. doi: 10.1177/1073858406290375.

DOI:10.1177/1073858406290375

PMID:16957005

Abstract

Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between minicolumns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism.

摘要

自闭症是一种表现为社交关系、沟通、兴趣范围及重复行为异常的病症。尽管患病率估计令人担忧且不断有人呼吁开展研究，但关于其病理生理学仍知之甚少。最近有关一种假定的微小柱病变的报告解释了脑容量、灰质/白质比例及区域间连接性的变化。本文总结了微小柱与自闭症病理生理学相关的其他主题——皮质模块化、发病年龄、胶质增生及遗传学——之间可能存在的联系。