Montemurro D, Rossi G P
DMCS-Internal Medicine 4, University of Padua, Padua, Italy.
J Endocrinol Invest. 2006 Jul-Aug;29(7):650-2. doi: 10.1007/BF03344166.
The administration of veralipride, a centrally acting dopaminergic type 2 (DA2) receptor antagonist, can decrease hot flushes and improve bone density in post-menopausal women (1). Therefore, it entails an alternative to hormone replacement therapy (HRT) in women who have contraindications to estrogen (1). We herein describe the case of a 52-yr-old lady who presented with an acute coronary syndrome shortly after taking veralipride. Based on knowledge that DA2 receptor antagonists trigger catecholamine release (2), a pheochromocytoma was suspected and thereafter diagnosed and excised. Therefore, this is the first case reporting on veralipride unmasking a silent pheochromocytoma.
维拉必利是一种中枢作用的多巴胺能2型(DA2)受体拮抗剂,服用该药可减少绝经后女性的潮热并改善骨密度(1)。因此,对于有雌激素禁忌证的女性而言,它是激素替代疗法(HRT)的一种替代选择(1)。我们在此报告一例52岁女性的病例,该患者在服用维拉必利后不久出现急性冠状动脉综合征。基于DA2受体拮抗剂可触发儿茶酚胺释放这一认识(2),怀疑其患有嗜铬细胞瘤,随后确诊并切除了肿瘤。因此,这是首例关于维拉必利揭示隐匿性嗜铬细胞瘤的病例报告。