一项确定单绒毛膜双胎结构性先天性心脏病发病率的研究。

A study to determine the incidence of structural congenital heart disease in monochorionic twins.

作者信息

Manning Nicky, Archer Nick

机构信息

Paediatric and Fetal Cardiology Service, John Radcliffe Hospital, Oxford, UK.

出版信息

Prenat Diagn. 2006 Nov;26(11):1062-4. doi: 10.1002/pd.1556.

DOI:10.1002/pd.1556

PMID:16958142

Abstract

OBJECTIVE

To determine the incidence of structural heart disease in at least one of a monochorionic (MC) twin pair excluding any cardiac effects of twin-twin transfusion syndrome (TTTS).

METHOD

A cohort study of 165 sets of MC twins undergoing detailed fetal echocardiography in a tertiary unit over a 4-year period.

RESULTS

The overall risk of at least one of a MC twin pair having a structural congenital cardiac anomaly was 9.1% (15/165); for monochorionic diamniotic (MC/DA) twins, this figure was 7.0% (11/158) but for monochorionic-monoamniotic (MC/MA) twins the risk for at least one affected twin was 57.1% (4/7). If one of a pair of MC twins was affected, the risk to the other twin for a structural cardiac anomaly was 26.7% (4/15).

CONCLUSIONS

The incidence of structural heart disease in MC twins is increased, independent of TTTS. This justifies referral of these pregnancies for detailed fetal echocardiography as part of their assessment. If one twin is affected, the risk to the other twin is increased further.

摘要

目的

确定单绒毛膜（MC）双胎中至少一胎患结构性心脏病的发生率，排除双胎输血综合征（TTTS）的任何心脏影响。

方法

一项队列研究，对165对MC双胎在4年期间于一家三级医疗单位接受详细胎儿超声心动图检查。

结果

MC双胎中至少一胎患有结构性先天性心脏异常的总体风险为9.1%（15/165）；对于单绒毛膜双羊膜囊（MC/DA）双胎，这一数字为7.0%（11/158），但对于单绒毛膜单羊膜囊（MC/MA）双胎，至少一胎受影响的风险为57.1%（4/7）。如果一对MC双胎中的一胎受影响，另一胎患结构性心脏异常的风险为26.7%（4/15）。