Gukovskaya Anna S, Mareninova Olga A, Odinokova Irina V, Sung Kai-Feng, Lugea Aurelia, Fischer Lars, Wang Yan-Ling, Gukovsky Ilya, Pandol Stephen J
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.
J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S10-3. doi: 10.1111/j.1440-1746.2006.04571.x.
Pancreatitis is a severe and frequently lethal disorder, a major cause of which is alcohol abuse. Parenchymal cell death is a major complication of pancreatitis. In experimental models of (non-alcoholic) acute pancreatitis, acinar cells have been shown to die through both necrosis and apoptosis, the two principal pathways of cell death. The severity of experimental acute pancreatitis correlates directly with the extent of necrosis and inversely with apoptosis. Thus, understanding the regulation of apoptosis and necrosis, and whether it is possible to manipulate the pattern of death responses, is becoming exceedingly important in investigations of the pathogenesis and treatment of pancreatitis. The effects of alcohol on cell death responses of pancreatitis, and the mechanisms that may mediate these effects, are just starting to be explored. This paper reviews the signaling pathways mediating the balance between apoptosis and necrosis in acute pancreatitis, and alcohol's effects on cell death responses in pancreatitis.
胰腺炎是一种严重且常致命的疾病，其主要病因之一是酗酒。实质细胞死亡是胰腺炎的主要并发症。在（非酒精性）急性胰腺炎的实验模型中，腺泡细胞已被证明可通过坏死和凋亡这两种主要的细胞死亡途径死亡。实验性急性胰腺炎的严重程度与坏死程度直接相关，与凋亡程度呈负相关。因此，了解凋亡和坏死的调控以及是否有可能操纵死亡反应模式，在胰腺炎的发病机制和治疗研究中变得极为重要。酒精对胰腺炎细胞死亡反应的影响以及可能介导这些影响的机制才刚刚开始被探索。本文综述了介导急性胰腺炎中凋亡与坏死平衡的信号通路，以及酒精对胰腺炎细胞死亡反应的影响。
